Human Papillomavirus (HPV) in Breast Tumors Coursework

Human Papillomavirus (HPV) in Breast Tumors - Coursework Example Thus, there is still an ongoing debate as to whether HPV causes breast cancer, and whether HPV vaccines can be used against it as well. Let’s look at two journal articles, published in year 2011, to exemplify such issue. Different Findings In the study of Antonsson et al. (2011), the prevalence of HPV in breast cancer tissue was determined through polymerase chain reaction (PCR) analysis and sequencing. Briefly, tissue samples were obtained from each of the fifty-four different fresh frozen breast cancer tissues obtained from surgeries at Wesley Hospital, Brisbane, Queensland, Australia between 2003 and 2007. The median age of these patients were 57 years old, with the age range of 31-88 years. 59% were post-menopausal, 63% were node-negative, and their mean tumour size was 24.3mm. According to the authors, this meant that HPV infection of breast cancer or HPV as an etiological agent decrease the metastatic potential of the tumour. To detect HPV, each sample was mixed with HPV general and type 18-specific primer pairs FAP59/FAP 64. After PCR, amplified products were analyzed using 1.5% agarose gel electrophoresis. 50% of the samples were found to be HPV-positive, specifically of HPV type 18, although the strains were different. Upon analyzing further, HPV-positive breast cancer patients (mean age = 50 y. o.) were found to be younger than the whole group, and HPV positive tumours were also found to be smaller than the others. Histologically, HPV positive samples (96.3%) were more likely to be ductal than HPV negative ones (85.2%). Aside from PCR, an in situ hybridization was also performed using INFORMÂ ® HPV III Family 16 Probe (B) (Roche Ventana Medical System, Tucson, Arizona) that can detect 16 different cancer-causing HPV types (HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, 73, and 82). However, no HPV were found in the samples using this method. The authors attributed this to the lower sensitivity of in situ hybridization as compared to PCR. Despite the results, the authors however recognized that their findings failed to determine whether the virus actually caused the breast cancer or it was just a chance passage for all 27 cases. As well, the potential mechanism behind the presence of HPV in the breast was still unanswered. A similar study was also conducted in India by Hedau et al. (2011). Breast tissue and blood samples from two hundred fifty two (252) breast cancer patients were analyzed through PCR using the general MY09/11, GP5+/GP6+ and type 16 specific E6/E7 as primers. The age of the participants were 51.5 Â ± 16.7, with a range of 25-80 years. 38% were postmenopausal. However, unlike that of Antonnson, the results of Hedau’s experiments showed absence of HPV DNA in breast cancer tissues. Social Implications In comparing the results of other similar studies conducted in different countries, Hedau et al. (2011) found that the breast tissue samples of a portion of breast cancer patients from Ital y, Sweden, China, Brazil, Austria, USA, Greece, Australia, Turkey, Japan, and Mexico were positive in HPV, with China and Mexico having more established results as more than one study have arrived at the same outcome of some breast cancer tissues being HPV-positive. On the other hand, studies in UK, India, Switzerland and France did not find HPV in breast

The Effects of Affirmative Action on Law Students and Lawyers :: Lawyers African American Essays

The Effects of Affirmative Action on Law Students and Lawyers Given the opportunity, do African Americans with lower undergraduate test scores and grades succeed in law school? Does admitting African Americans with lower test scores and grades than other racial groups into law schools have a good or bad effect on American society? On one hand it can be argued these students grab the opportunity and use it. Making more African American lawyers is healthy for American society. The presence of more African American lawyers itself means the concerns of their community will be heard and represented in society. Seeing successful African American lawyers will prove to frustrated African American high school students that this really is the land of opportunity in which success is available to those who work hard. On the other hand it can be argued poorly qualified undergraduates drop out of law school or just learn just enough to pass the bar examinations after several tries. This process has a very bad effect on society. By giving prefere nce to less qualified African American students the result is lawyers of poor quality. Poor quality workers produce poor quality work, which in the long run is not good for society. People point to the 1980’s as an example where poor quality American automobiles were rejected by buyers who turned to higher quality Japanese cars. The article â€Å"The Scandal of the Law Schools† by Stephan Thernstrom in the December 1997 issue of Commentary presents both sides of this debate. This article takes information from a study by Linda Wightman favoring preferences and uses it to make the author’s points against preferences. Although this article clearly opposes racial preferences, it does include enough of Linda Wightman’s arguments that a reader is left at the end to make up his/her mind of what the truth is or what needs further study. Commentary is a magazine published by the American Jewish Association and has an objective of trying to unify by publishing a variety of articles of different views. The American Jewish intellectual community has the reputation of being liberal, but this magazine has a history of being conservative. As a historically oppressed minority itself, the American Civil Rights Movement and Dr.

Book Analysis: The Science of Muddling Through

A Summary of: The Science of â€Å"Muddling Through† By Charles E. Lindblom Public Administration Review, Vol. XIX, No. 2 (Spring, 1959), 79-88 I. Introduction This article discusses two different strategies for comparing policies. The first strategy, Lindblom entitles Root, or Rational-Comprehensive Lindblom refers to the second strategy as Branch, or Successive Limited Comparisons. After a brief explanation of the two systems, he goes on to argue the superiority of the Branch system over the more commonly discussed Root system II. RootThe Root approach, or Rational-Comprehensive, is best utilized for more simple problems, according to Lindblom, due to the necessitation of massive intellectual capacities and sources of information. He states that this approach is generally not correct for policy analysis, as time and money are restrictions in these scenarios. He also states that public agencies are effectively instructed not to practice the root method, due to political or le gal constraints Ironically, the common literature tends to preach formalization of this method. This leads to many practitioners acting against the philosophy commonly published.Lindblom lists the characteristics of the Root approach as the following:Clarification of values or objectives distinct from and usually prerequisite to empirical analysis of alternative policies.Policy-formulation is therefore approached through means-end analysis: First, the ends are isolated, then the means to achieve them are sought.The test of a â€Å"good† policy is that it can be shown to be the most appropriate means to desired ends.Analysis is comprehensive; every important relevant factor is taken into account.Theory is often heavily relied upon.As this theory is often discussed, Lindblom assumes it is familiar to the reader and shifts his focus to explaining and clarifying the alternative. Most of the article revolves around the Branch approach, or Successive Limited Comparisons. III. Branc h The Branch Approach, or Successive Limited Comparisons is the approach Lindblom claims most administrators use for their approach to understanding complex problems. Lindblom assigns the following characteristics to the Branch approach:Selection of value goals and empirical analysis of the needed action are not distinct from one another but are closely intertwined. Since means and ends are not distinct, means-end analysis is often inappropriate or limited.The test of a â€Å"good† policy is typically that various analysts find themselves directly agreeing on a policy (without their agreeing that it is the most appropriate means to an agreed objective).Analysis is drastically limited:Important possible outcomes are neglected.Important alternative potential policies are neglected.Important affected values are neglected.A succession of comparisons greatly reduces or eliminates reliance on theory.The Branch approach could be illustrated as continually building out from the curre nt situation, slowly, by small degrees, one step at a time. Lindblom then elaborates on the Branch approach throughout the remainder of the article. a. Intertwining Evaluation and Empirical Analysis In this section, Lindblom explains how the Root method breaks down its handling of objectives and values. He states that clarifying values prior to investigating alternative policies produces several problems. The first problem is that citizens, congressmen, and public administrators frequently disagree on many critical values.Second, even when an administrator opts to choose his own value set for guidance, he often will not know how to rank conflicting criterion. A third problem arises concurrent to the previous two â€Å"Social objectives do not always have the same relative values. † These common problems often lead administrators to ask a question like the following: â€Å"Given the degree to which we are or are not already achieving the values of good public relations, is it worth sacrificing a little speed for a happier clientele, or is it better to risk offending the clientele so hat we can get on with our work? †The answer, of course, varies according to the situation. The particular difficulty with values is the issue with attempting to state marginal objectives in forms other than particular policies. This leaves administrators attempting to choose between policies that offer different marginal combinations of values. Lindblom closes this argument with two summarizing points. First, for complex problems, the Root system is impossible and irrelevant, while the Branch method is possible and relevant.The Branch method is possible because the administrator does not need to attempt to analyze any values except those where the alternative policies differ, and this differentiation is only notable marginally. This drastically reduces the need for collecting information on values or objectives, which keeps the capacity for comparing values within rea son. b. Relations Between Means and Ends Generally, and according to the Root method, decision-making is considered to be a means-ends relationship.The means are to be evaluated and selected depending upon the ends which is selected independently and before choosing the means. But this is difficult unless the values have been agreed upon and are stable at the margin. This relationship between the means and the ends does not exist with the branch method, as both are chosen simultaneously. c. The Test of â€Å"Good† Policy Under the Root method, a decision can be considered correct if it can be shown to attain some specified objective. This objective must be defined beyond just describing the actual decision.If administrators cannot agree on the objectives, the Root method offers no test For the Branch method, the test is agreement on the actual policy, which may be possible even when agreement on values has proven impossible. Different ideologies can agree on different policie s, even if the agreement is based on different reasoning. Lindblom states that â€Å"agreement on policy thus becomes the only practicable test of the policy’s correctness. † The Branch method relies upon agreement whenever possible. d. Non-Comprehensive Analysis It is impossible to take every important aspect of a problem into onsideration unless the problem is very narrowly defined, therefore limiting analysis. Simplification of complex problems is imperative.Lindblom illustrates that under the Root method, simplification is achieved systematically through limitation of policy comparisons to those policies that differ in relatively small degree from policies presently in effect. It is only necessary to study the aspects in which the alternatives and their consequences differ from the current norm. This limitation reduces the alternatives under consideration and simplifies the investigation of each of these alternatives.It only becomes necessary to study the respects in which the proposed alternative and its consequences differ from that norm. i. Relevance as Well as Realism In the west, policy analysts tend to limit their analysis to marginal differences in policies that are chosen to differ incrementally. Democracies tend to change policies incrementally. By simplifying the policy by limiting the focus to slight deviations, the most value is made of available information. â€Å"Non-incremental policy proposals are therefore typically not only politically irrelevant, but also unpredictable. †Another way to simplify analysis is by ignoring important potential consequences of the possible policies, and also ignoring the values associated with those neglected consequences. Even if the exclusions are made at random, the policies may be formulated more intelligently than by attempting to achieve a comprehensiveness which is too extensive. ii. Achieving a Degree of Comprehensiveness The potential for losing important values is present in any o rganization. The benefit of a hypothetical division of labor is that every important value has its own watchdog; these watchdogs can guard their respective interests in two ways.First, they may redress damages done by other agencies. Second, they may anticipate and avoid injury before it happens. In the United States, no part of government attempts comprehensive policy overviews on things such as income distribution, yet a policy evolves. This incremental policy-making pattern fits with the multiple pressure pattern. When this particular type of policy-making model is followed, it is easier for one group to anticipate the moves of another group. It is also easier for these groups to make adjustments for injuries already accomplished.Administrative coordination occurs as each of these agencies adjusts its policies according to the concerns of the other agencies in a fragmented form of decision-making. Branch method exclusions are deliberate and systematic, yet it does not necessarily disregard long-run considerations. Sometimes the only way long-run objectives can be given enough attention is through neglecting the short-term considerations. e. Succession of Comparisons The last element concerns the comparisons. These comparisons proceed in a chronological order. When the policy maker uses a succession of incremental changes, serious lasting mistakes can be avoided.First, he learns from past sequences of policy steps, and gains knowledge of the probable consequences of similar steps. Second, he can avoid big jumps that may require predictions he does not possess the knowledge to adequately make. This is because he never expects his policy to be the final resolution. Third, he is able to test his previous predictions as he slowly moves on to the proceeding steps. Fourth, past errors can be fixed relatively quickly. For policy-making purposes, the analyst need only know the consequences of each of the policy aspects as they differ from the others. iii. Theorists and PractitionersThe Branch system explains why administrators often feel that outside experts are not helpful and would rather work off of gut instinct than following the advice proposed by theorists. Lindblom gives two reasons why theory can have limited applicability in policy-making. First, it is greedy for facts and can be construed only through a great collection of observations. Second, it is generally insufficiently precise for application to a policy process that moves through small changes. Only in restricted areas is economic theory precise enough to become particularly helpful when resolving policy questions. v. Successive Comparison as a System Lindblom concludes that the Branch system is indeed a legitimate system, despite its imperfections.He reminds the reader that the Branch method lacks a built-in safeguard for all relevant values, and it may lead the decision-maker to overlook potential policies simply because they are not suggested. One of the benefits of clarify ing this method is â€Å"the light it throws on the suspicion an administrator sometimes entertains that a consultant or adviser is not speaking relevantly and responsibly when in fact by all ordinary objective evidence he is. While much of organization theory argues the virtues of common values and agreed organizational objectives, for complex problems in which the root method is inapplicable, agencies will want among their own personnel two types of diversification: administrators whose thinking is organized by reference to policy chains other than those familiar to most members of the organization and, even more commonly, administrators whose professional or personal values or interests create diversity of view†¦ so that, even without a single agency, decision-making can be fragmented and parts of the agency can serve as watchdogs for other parts.IV. Conclusion Lindblom’s argument basically attempts to legitimize the decision-making processes that are already frequen tly in use. He points out a gap between the theory advocated by policy academics and the real-world problems faced by decision-makers. He explains how and why the current work-around is legitimate and worthy of acceptance. The Branch method, as he calls it, simply needs to be recognized as having merit. By pointing this out and attempting to define the Branch method and its attributes, he is opening the door for academics to begin theorizing on this method, as well.

The Questions Every Entrepreneur Must Answer - 6813 Words

†¢ , what are my goals} Do I have the right strategy^ Can I execute the strategy I The Questions Every Entrepreneur by Amar Bhide Of the hundreds of thousands of husiness ventures that entrepreneurs launch every year, many never get off the ground. Others fizzle after spectacular rocket starts. A six-year-old condiment company has attracted loyal custoiners but has achieved less than $500,000 in sales. The company s gross margitis can t cover its overhead or provide adequate incomes for the founder and the family members who participate in the business. Additional growth will require a huge capital infusion, but investors and potential buyers aren t keen on srnall, rnarginally profitable ventures, and the family has†¦show more content†¦Instead, it helps entrepreneurs pose useful questions, identify itnportant issues, and evaluate solutions. The framework applies whether the enterprise is a stnall printing shop trying to stay in husiness or a catalog retailer seeking hundreds of milliotis of dollars in sales. And it works at almost any point in a venture s evolution. Entrepreneurs should use the framew ork to evaluAmai Bhide is an associate professor at the Harvard Business School in Boston, Massachusetts, where he leaches entiepreneurship. He has published two other HBR articles on entrepreneurship: Bootstrap Finance: The Art of Start-ups (Novemher-Deeemher 1992} and How Entrepreneurs Craft Strategies That Work (March-April 1994). 121 QUESTIONS FOR ENTREPRENEURS ate their companies position and trajectory often not just when problems appear. The framework consists of a three-step sequence of questions. The first step clarifies entrepreneurs current goals, the second evaluates their strategies for attaining those goals, and the third helps them assess their capacity to execute their strategies. The hierarchical organization of the questions requires entrepreneurs to confront the basic, big-picture issues hefore they think about refinements and details. (See the exhibit An Entrepreneur s Guide to the Big Issues.) This approach does not assume that all companies-or all entrepreneurs - develop in the same way, so it does notShow MoreRelatedQuestions Every Entrepreneur Must Answer -Summary Essay818 Words   |  4 PagesThe questions every entrepreneur must answer Preface Entrepreneurs must continually ask themselves what business they want to be in and what capabilities they would like to develop. The Entrepreneur must distinguish critical issues from normal growing pains (divide and conquer). The options that are appropriate for one entrepreneurial venture may be completely inappropriate for another. The article’s suggested framework: The first step clarifies the entrepreneurs’ current goals. The secondRead MoreA Brief Note On Effective Social Media Marketing Essay995 Words   |  4 PagesAuthor Lori A Manns Social media is here to stay. As an entrepreneur or small business owner if you re not using it to grow your business you are missing out. I am sure you have seen the statistics by now. In 2015, 73 percent of U.S. Americans had a social network profile, representing a six percent growth compared to the previous year according to Statista. The numbers do not lie. Social media is a way of life all over the globe. As an entrepreneur or small business owner if you re not using socialRead MoreUses of Scientific Methods in Business1174 Words   |  5 Pagesthings look or act the way they do. Scientific research consists of intrusiveness, observations, experiments and evaluations. It attempts to use these to answer questions about what causes differing phenomena. It is important to note that scientific research does not provide absolute solutions to questions, but preferably gives apparent answers based on, evidence gathered and contemporary knowledge. New information can lead to the denial of ideas previously believed to be true. This article is aboutRead MoreWho Is A Successful Entrepreneur?948 Words   |  4 PagesAccording to the first segments on the TSBDC training website, one does not have to have a certain personality in order to be a successful entrepreneur. One does, however, have to obtain certain personality traits, or characteristics, to truly have what it takes to become a successf ul entrepreneur. For example, a person who lacks confidence, is shy and uncomfortable breaking rules or not willing to work as hard to find opportunities will most definitely struggle in entrepreneurship. On the otherRead MoreHow The Business Run Base On 3 Essential Elements917 Words   |  4 PagesPart three of The Lean Startup talked about how to make your entrepreneur go smoothly. Eric Ries, the author of this book, gave us an idea about how the business run base on 3 essential elements: Build, Measure, and Learn. In Eric’s opinion, build means turn your ideas into product, and keep going with that idea. However, when you carry out that idea, you must capture your customer’s need to minimize wasted product. Furthermore, measure in Eric’s perspective means see how customer responds by observingRead MoreCase Study Guidelines Motivation and Leadership Essay689 Words   |  3 PagesCompany Todd McFarlane, president and CEO of the McFarlane Companies, is an entrepreneur who understands the importance of product development. Comics, sports, toys, and rock-and-roll have all benefited from his creativity. When McFarlane’s dream to play major league baseball didn’t happen, he fell back on another interest he developed as a teenager—drawing superheroes. He faced the same question faced by all entrepreneurs: Could he make money pursuing his dream? He sent his sketches to prospectiveRead MoreStrategic Management Growth Oriented Timber Haulage Entrepreneurs1458 Words   |  6 PagesThe ‘’Successful Strategic Management Growth-Oriented Timber Haulage Entrepreneurs’’ describes what kind of strategic management develop to achieve growth profitability. Also, this research emphasizes the importance of strategic management. Strategic management involves the implementation of setting objectives, policies and goals. The most important fa ctor to achieve a successful growth and sustainability is taken by the executive manager and owners. Executive managers has the commitment to reachRead MoreEntrepreneurship Is A Nature Or Nurture Process Essay1468 Words   |  6 Pagesprominent discussion relates to whether entrepreneurship is a nature or nurture process. In order to answer this question, entrepreneurship must first be defined. As it is a multi-faceted field that spans across a wide range of contexts, there is no agreed definition of entrepreneurship (Schaper, 2014). For the context of this essay, however, it is a process that brings together a team- with a leading entrepreneur-, an opportunity, the right resources, an organisation, and an appropriate environment (MasseyRead MorePutting A Successful Business : Peter Thiel1102 Words   |  5 Pages Peter Thiel is a venture capitalist and entrepreneur who co-founded companies such as, Pay-Pal and Palantir. In his book Zero to One, Thiel talks about the essential steps to follow in creating a successful business. According to Thiel, in order to create a successful business the founder must create a new product that has never been done before. He talks about the horizontal and vertical process of businesses. The horizontal process focuses on the idea of doing more of what is already workingRead MoreThe Importance Of Literacies On Entrepreneurial Endeavors1425 Words   |  6 Pagescornerstone for modern progress and creation of new ideas, or entrepreneurship. Becoming a successful entrepreneur is dependent on possessing and improving upon the ability to read text, people, and situations. Literacies are integrated into the nature of entrepreneurship, as will be discussed with a current successful business owner, and the ability to be literate can determine success as an entrepre neur. Literacy is a very common word. However, in such an advanced world, the definition of literacy has